Purification and Characterization of Organic Compounds | Purification - Crystallization, sublimation, distillation, differential, extraction and chromatography principles and their application. Qualitative Analysis - Detection of nitrogen, sulphur, phosphorus and halogens. Quantitative Analysis - Estimation of carbon, hydrogen, nitrogen, halogens, sulphur, and phosphorus. Calculations of empirical formulae and molecular formulae, Numerical problems in organic quantitative analysis.
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Some Basic Principles of Organic Chemistry | Tetravalency of carbon, Shapes of simple molecules - hybridization, Classification of organic compounds on functional groups and those containing halogens, oxygen, nitrogen and sulphur, Homologous series, Isomerism - Structural and Stereoisomerism. Nomenclature (Trivial and IUPAC) - Covalent bond fission - Homolytic and heterolytic: free radicals, carbocations and carbanions, stability of carbocations and free radicals, electrophiles and nucleophiles. Electronic displacement in a covalent bond - Inductive effect, electromeric effect, resonance and hyperconjugation. Common types of organic reactions - Substitution, addition, elimination and rearrangement.
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Hydrocarbons | Classification, isomerism, IUPAC nomenclature, general methods of preparation, properties and reactions. Alkanes - Conformations: Sawhorse and Newman projections of ethane, Mechanism of halogenation of alkanes. Alkenes - Geometrical isomerism, Mechanism of electrophilic addition: addition of hydrogen, halogens, water, hydrogen halides ( Markownikoff and peroxide effect) , Ozonolysis and polymerization. Alkynes - Acidic character, addition of hydrogen, halogens, water and hydrogen halides, Polymerization. Aromatic hydrocarbons - Nomenclature, benzene - structure and aromaticity, Mechanism of electrophilic substitution: halogenation, nitration, Friedel - Craft’s alkylation and acylation, directive influence of the functional group in mono-substituted benzene.
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Organic Compounds Containing Halogens | General methods of preparation, properties and reactions, Nature of C-X bond, Mechanism of substitution reactions. Uses, Environmental effects of chloroform, iodoform freons and DDT.
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Organic Compounds Containing Oxygen | General methods of preparation, properties, reactions and uses. Alcohols, Phenols and Ethers Alcohols - Identification of primary, secondary and tertiary alcohols, mechanism of dehydration. Phenols - Acidic nature, electrophilic substitution reactions, halogenation, nitration and sulphonation, Reitner - Tiemann reaction Ethers - Structure Aldehyde and Ketones - Nature of carbonyl group, Nucleophilic addition to >C=0 group, relative reactivities of aldehydes and ketones, Important reactions such as - Nucleophilic addition reactions, Grignard reagent, oxidation, reduction (Wolff Kishner and Clemmensen), acidity of a-hydrogen, aldol condensation, Cannizarro reaction, Haloform reaction Chemical tests to distinguish between aldehydes and Ketones Carboxylic Acids - Acids strength and factors affecting it.
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Organic Compounds Containing Nitrogen | General methods of preparation, properties, reactions and uses. Amines - Nomenclature, classification, structure, basic character and identification of primary, secondary and tertiary amines and their basic character. Diazonium Salts - Importance in synthetic organic chemistry.
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Biomolecules | General introduction and importance of biomolecules. Carbohydrates - Classification: aldoses and ketoses, monosaccharides (glucose and fructose) and constituent monosaccharides of oligosaccharides (sucrose, lactose and maltose). Proteins - Elementary idea of a-amino acids, peptide bonds, and polypeptides. Proteins: primary, secondary, tertiary and quaternary structure (qualitative idea only), denaturation of proteins, enzymes. Vitamins - Classification and functions. Nucleic Acids - Chemical constitution of DNA and RNA. Biological functions of nucleic acids.
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Principles Related to Practical | Detection of extra elements (N, S, halogens) in organic compounds, Detection of the following functional groups: hydroxyl (alcoholic and phenolic), carbonyl (aldehyde and ketone), carboxyl and amino groups in amino compounds. Chemistry is involved in the preparation of the following: - Inorganic compounds - Mohr’s salt, potash alum.
- Organic compounds - Acetanilide, p nitro acetanilide, aniline yellow, iodoform.
Chemistry involved in the titrimetric exercises - Acids bases and the use of indicators, oxalic-acid vc KMnO, Mohr’s salt vs KMnO Cations - Pb2+, Cu!+, Af,+, Fe1+, Zn2+, Ni2+, Ca2+, Ba2+, Mg2+, nh;. Anions- CO,", S2~, SO4", NO", NO~2, Cf, Br", I". (Insoluble salts excluded). •Chemical principles involved in the following experiments: 1. Enthalpy of solution of CuS04 2. Enthalpy of neutralization of strong acid and strong base. 3. Preparation of lyophilic and lyophobic sols. 4. Kinetic study of the reaction of iodide ions with hydrogen peroxide at room temperature. |